Recent Neonatal Kidney Publications

Neonatal hypertension: concerns within and beyond the neonatal intensive care unit

1 month ago
Neonatal hypertension occurs in 1-2% of neonates in the neonatal intensive care unit (NICU) although may be underdiagnosed. Blood pressure values in premature neonates change rapidly in the first days and weeks of life which may make it more difficult to recognize abnormal blood pressure values. In addition, the proper blood pressure measurement technique must be used to ensure the accuracy of the measured values as most blood pressure devices are not manufactured specifically for this...
Kathleen Altemose

Role of the Ubiquitin Ligase RNF149 in the Development of Rat Neonatal Gonocytes

1 month ago
Male reproductive function depends on the formation of spermatogonial stem cells from their neonatal precursors, the gonocytes. Previously, we identified several UPS enzymes dynamically altered during gonocyte differentiation. The present work focuses on understanding the role of the RING finger protein 149 (RNF149), an E3 ligase that we found to be strongly expressed in gonocytes and downregulated in spermatogonia. The quantification of RNF149 mRNA from postnatal day (PND) 2 to 35 (puberty) in...
Gurpreet Manku

Expression and Immunogenicity of Recombinant African Swine Fever Virus Proteins Using the Semliki Forest Virus

1 month 1 week ago
African swine fever virus (ASFV) is a large DNA virus belonging to the Asfarviridae family that damages the immune system of pigs, resulting in the death or slaughter of millions of animals worldwide. Recent modern techniques in ASFV vaccination have highlighted the potential of viral replicon particles (RPs), which can efficiently express foreign proteins and induce robust cellular and humoral immune responses compared with the existing vaccines. In this study, we established a Semliki Forest...
Niran Fang

Type 4 Ileal Atresia and Anorectal Malformation in a Neonate: A Rare Association

1 month 1 week ago
Anorectal malformations and jejunoileal atresias are common causes of intestinal obstruction in neonates. Both have their own set of associated anomalies but it is extremely rare for the two to co-occur in the same patient. In this case report, we detail and describe this unusual incidence in a three-day-old neonate who was provisionally diagnosed with a case of simple imperforate anus. Per-op findings showed a type 4 Ileal atresia and an ileostomy was then created. Our experience stresses the...
Munema Khan

Assessment of adherence to aspirin for preeclampsia prophylaxis and reasons for non-adherence

1 month 2 weeks ago
BACKGROUND: Preeclampsia is a hypertensive disease unique to pregnancy and has a significant impact on maternal and neonatal morbidity and mortality. Daily aspirin has been demonstrated to reduce the risk of preeclampsia. The American College for Obstetricians and Gynecologists (ACOG) recommends daily low-dose aspirin initiation, ideally prior to 16 weeks gestation, in at-risk patients for preeclampsia risk reduction. This study examined whether patients at risk for preeclampsia by ACOG criteria...
Danielle N Olson

The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro

1 month 2 weeks ago
Remdesivir is a prodrug of a nucleoside analog and the first antiviral therapeutic approved for coronavirus disease. Recent cardiac safety concerns and reports on remdesivir-related acute kidney injury call for a better characterization of remdesivir toxicity and understanding of the underlying mechanisms. Here, we performed an in vitro toxicity assessment of remdesivir around clinically relevant concentrations (C(max) 9 µM) using H9c2 rat cardiomyoblasts, neonatal mouse cardiomyocytes (NMCM),...
Katja Merches

Two Cases With Neonatal Cholestasis and Renal Disorders Due to DCDC2 Mutation

1 month 2 weeks ago
Ciliopathies are a heterogeneous group of diseases that are observed after deterioration of the ciliary structures on the cell surface that facilitate communication with the environment. Both liver and kidney involvement are frequently observed in this disease. Recently, a doublecortin domain containing protein 2 (DCDC2) mutation in a ciliopathy disease group was identified. Here, we present 2 patients with this mutation and with neonatal cholestasis and renal involvement.
Demet Teker Düztaş

Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study

1 month 2 weeks ago
CONCLUSIONS: This is the largest prospective, multicentre study specifically looking at neonatal AKI and need for dialysis in neonates. AKI was seen in 30.7% of neonates (with the need for acute PD in 9% of the AKI group). The odds of needing acute PD were significantly higher among those with significant cardiac disease, inotropes usage, severe peripartum event, requirement of respiratory support in NICU, necrotising enterocolitis, any grade of intraventricular haemorrhage, evidence of fluid...
Sidharth Kumar Sethi

Anti-infective Medicines Use in Children and Neonates With Pre-existing Kidney Dysfunction: A Systematic Review

1 month 3 weeks ago
CONCLUSION: This is the first systematic review providing evidence of the use of anti-infective medicines in pediatric patients with impaired kidney function or requiring KRT. Dosing size or interval adjustments in pediatric patients with kidney impairment vary according to age, critical illness status, decreased kidney function and dialysis type. Our findings underline the relevance of population PK in clinical practice and the need of developing predictive specific models for critical...
Chiara Minotti

Mechanical stretch-driven ROS generation stimulates endothelin production in neonatal pig renal epithelial and vascular endothelial cells

1 month 3 weeks ago
The circulating level of endothelin (ET), a potent vasoactive peptide, decreases with postnatal age. ET is also of pathophysiological significance in the kidney. ET is generated via endothelin converting enzyme (ECE)-induced proteolytic processing of pro-molecule big ET to biologically active peptides. Hydrogen peroxide (H(2) O(2) ), a reactive oxygen species (ROS), transactivates the promoter of ECE1. Oxyradicals contribute to kidney pathophysiology, but whether ROS regulates ET production in...
Ravi Kumar

Severe Fetal CAKUT (Congenital Anomalies of the Kidneys and Urinary Tract), Prenatal Consultations, and Initiation of Neonatal Dialysis

1 month 3 weeks ago
CONCLUSION: Many pediatric nephrology programs provide prenatal CAKUT consultations and neonatal dialysis, but with variability in practice approach. Further multi-center research regarding prenatal consultations and neonatal dialysis outcomes is necessary to further improve care delivery to this population.
Keia Sanderson

COVID-19 Increases Markers of Endothelial Damage in Normotensive Pregnant Women

1 month 3 weeks ago
COVID-19 (CV19) is a disease caused by SARS-CoV-2 and has caused a pandemic since discovered in 2019, resulting in over 5 million deaths worldwide. The impact of CV19 on pregnancy are still under investigation and are potentially long-lasting. However studies have reported that pregnant women affected by CV19 have an increased risk of preterm delivery, pregnancy complications, organ failure, respiratory distress, increased inflammation, increased hospitalization and poor fetal outcomes compared...
Shauna-Kay Spencer