Recent Neonatal Kidney Publications

Association of Chronic kidney dysfunction and preeclampsia: Insights of the Nationwide Inpatient Sample

1 week 3 days ago
CONCLUSIONS: Our data adds to the prior findings that patients with chronic kidney disease are at increased risk of developing preeclampsia even in the modern era of medical management, independent of the cause of chronic kidney disease. Racial/ethnical and geographical differences in chronic kidney disease prevalence exist. A multi-disciplinary team approach to follow pregnant patients with chronic kidney disease could decrease the maternal and neonatal mortality.
Stefanie Marek-Iannucci

Liver disease in GLIS 3 mutations - Transplant considerations and bile duct paucity on explant histology

1 week 4 days ago
GLI-similar 3 (GLIS3) gene mutation heterozygosity is characterised by neonatal diabetes and hypothyroidism. It has wide phenotypic variability. Liver disease is prevalent, and its complications in some phenotypes are life-limiting. Transplantation and the pathogenesis of GLIS3 liver disease are not well explored in the literature. We report two cases of children with GLIS3 mutations with chronic liver disease who required liver transplantation and we present a literature review discussing the...
Michael R Couper

Circadian Rhythm Disruption in Critically Ill Patients

1 week 4 days ago
Patients admitted to the intensive care unit (ICU) are in need of continuous organ replacement strategies and specialized care, e.g. because of neurological dysfunction, cardio-pulmonary instability, liver or kidney failure, trauma, hemorrhagic or septic shock or even preterm birth. The 24-hour nursing and care interventions provided to critically ill patients significantly limit resting and/or recovery phases. Consecutively, the patient's endogenous circadian rhythms are misaligned and...
Matthias Felten

Clinical Outcome of Ultrasound-Detected Perforated Necrotizing Enterocolitis without Radiographic Pneumoperitoneum in Very Preterm Infants

2 weeks ago
CONCLUSIONS: Very preterm infants with US-detected perforated NEC without radiographic pneumoperitoneum had a lower risk of death before discharge than those with perforated NEC and radiographic pneumoperitoneum. Bowel USs may have a potential role in surgical decision-making in infants with advanced NEC.
Myoung Kyoung Kim

Podocytopathy Associated with IgA Nephropathy in Pregnancy: A Challenging Association

2 weeks ago
IgA nephropathy is the most common form of primary glomerulonephritis. While associations of IgA and other glomerular diseases have been described, the association of IgA nephropathy with "primary" podocytopathy is rare and has not been reported in pregnancy, due in part to the infrequent use of kidney biopsy during pregnancy, and a frequent overlap with preeclampsia. We report the case of a 33-year-old woman with normal kidney function, referred in the 14th gestational week of her second...
Alejandra Orozco Guillén

Intestinal prolapse and exposure after peritoneal dialysis in low-birth-weight preterm infants with acute renal failure: a case report

2 weeks 2 days ago
CONCLUSIONS: The PD method effectively treats low-birth-weight preterm neonates with AKI. An adult Tenckhoff catheter was shortened by 2 cm and successfully used in the PD treatment of a low-birth-weight preterm infant. However, the catheter placement should be outside the skin, and the incision should be as small as possible to avoid leakage and incision tears.
Hong-Ying Jiang

Activation of renal vascular smooth muscle TRPV4 channels by 5-hydroxytryptamine impairs kidney function in neonatal pigs

2 weeks 3 days ago
Control of microvascular reactivity by 5-hydroxytryptamine (5-HT; serotonin) is complex and may depend on vascular bed type and 5-HT receptors. 5-HT receptors consist of seven families (5-HT(1)-5-HT(7)), with 5-HT(2) predominantly mediating renal vasoconstriction. Cyclooxygenase (COX) and smooth muscle intracellular Ca^(2+) levels ([Ca^(2+)](i)) have been implicated in 5-HT-induced vascular reactivity. Although 5-HT receptor expression and circulating 5-HT levels are known to be dependent on...
Jeremiah M Afolabi

Current and potential methods to assess kidney structure and morphology in term and preterm neonates

2 weeks 3 days ago
After birth, the kidney structure in neonates adapt to the functional demands of extrauterine life. Nephrogenesis is complete in the third trimester, but glomeruli, tubuli, and vasculature mature with the rapidly increasing renal blood flow and glomerular filtration. In preterm infants, nephrogenesis remains incomplete and maturation is slower and may be aberrant. This structural and functional deficit has life-long consequences: preterm born individuals are at higher risk for chronic kidney...
Eveline Staub

A meta-analysis of pregnancy outcomes in the diagnosis of isolated foetal renal parenchyma by prenatal ultrasonography

2 weeks 5 days ago
CONCLUSION: The indications for eugenic labour should not be included in a prenatal ultrasound diagnosis of patients with IHEK. In the results of this meta-analysis, the live birth and polycystic dysplasia rates were optimistic in terms of pregnancy outcomes. Therefore, under the condition of excluding other unfavourable factors, it is necessary to A thorough technical inspection is required to make an accurate judgment.
Changzhong Li

Neonatal urinoma associated with ascites in a newborn with a solitary kidney

2 weeks 5 days ago
Fetal urinomas are often diagnosed in prenatal ultrasonography. The etiology is usually an obstructive uropathy leading to hydronephrosis and increased intrarenal pressure putting future kidney function at risk. Rupture of pyelocaliceal system in such cases may lead to retroperitoneal urinoma or urinary ascites, sepsis, uraemia, and acute renal failure. On the other hand, this may serve as "pop-off valve" mechanism decreasing intrarenal pressure and protecting from definitive kidney function...
Emil Dorosiev

A Case Report of IPEX Syndrome with Neonatal Diabetes Mellitus and Congenital Hypothyroidism as the Initial Presentation, and a Systematic Review of neonatal IPEX

3 weeks 1 day ago
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is a serious disorder, which may comprise diabetes, thyroid disease, enteropathy, cytopenias, eczema, and other multi-system autoimmune dysfunction features. IPEX syndrome is caused by mutations in the forkhead box P3 (FOXP3) gene. Here, we report the clinical manifestations of a patient with IPEX syndrome onset in the neonatal period. A de novo mutation at exon 11 of the FOXP3 gene (c.1190G > A, p.R397Q) was found,...
A-Na Hou

A Neonatal Murine Model for Caprine Enterovirus Infection and the Viral Tissue Tropism

3 weeks 4 days ago
As the first caprine enterovirus identified from goat herds characterized by severe diarrhea with a high morbidity and mortality rate, the underlying pathogenesis and tissue tropism for CEV-JL14 remains largely unknown. Here, we reported the establishment of a neonatal murine model for caprine enterovirus and the unveiling of the tissue tropism and underlying pathogenesis for CEV-JL14 enterovirus. Susceptible murine strains, the infective dose, the infective routes, viral loads, and tissue...
Qun Zhang

Case report: Applicability of breastfeeding the child of a patient with kidney failure with replacement therapy

3 weeks 5 days ago
This case report highlights the benefit or harm of breastfeeding in a patient with Kidney Failure with Replacement Therapy (KFRT) undergoing program hemodialysis. This is a unique clinical case, as pregnancy and successful delivery are rare in this group of females. With a favorable outcome, the possibility of breastfeeding is especially relevant for doctors and the mother. The patient was a 31-year-old female who was diagnosed in 2017 with end-stage renal disease associated with chronic...
Elena V Kondakova