Recent Neonatal Kidney Publications

Neonatal polycystic kidney disease: a novel variant

1 day 21 hours ago
Polycystic kidney disease (PKD) is a condition typified by multiple renal cysts and renal enlargement. Classification is usually determined by mode of inheritance-autosomal dominant PKD (ADPKD) or autosomal recessive PKD (ARPKD). ARPKD frequently presents in fetal life, but here we report a rare case of a family with two siblings diagnosed with ADPKD manifesting in utero with novel genetic findings. During the first pregnancy, enlarged cystic kidneys were noted at the gestational age (GA) of 18...
Catherine Finnegan

Pregnancy care in solid organ transplant recipients

1 week 6 days ago
Recipients of solid organ transplants who become pregnant represent an obstetrically high-risk population. Preconception planning and effective contraception tailored to the individual patient is critical in this group. Planned pregnancies improve both maternal and neonatal outcomes and provide a window of opportunity to mitigate risk and improve lifelong health. Optimal management of these pregnancies is not well defined. Common pregnancy complications after transplantation include...
Aneesh Kallapur

Analysis of lesions of liver in autopsy

2 weeks 2 days ago
CONCLUSIONS: The pattern of liver diseases is different in the different ethnic groups. In India, no such study is available. Autopsy study may have clearer picture of lesions of liver than what we see in liver biopsy, which may be used for academic & research purposes.
Amar Ranjan

Ear Acupuncture Points in Neonates From Drug-Dependent Mothers: A Prospective Study

2 weeks 4 days ago
Aim: The aim of the study was to determine the presence or absence of ear acupuncture points (EAP) in newborn children with or without neonatal abstinence syndrome (NAS) and to confirm the hypothesis that neonates with NAS have more EAP than healthy neonates. Methods: We conducted a prospective case control study with ethical consent at the University Children's Hospital, Division of Neonatology Bern and the Department of Gynecology and Obstetrics Inselspital Bern in Switzerland. We determined...
Kirsten Stähler van Amerongen

Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers

2 weeks 4 days ago
Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their architecture and the cell types detectable at histology. In preterm neonates, these differences are even more evident, due to the lower level of organ maturation and to ongoing cell differentiation. One of the most remarkable finding in preterm tissues is the presence of huge amounts of stem/progenitor cells in multiple organs, including kidney, brain,...
D Fanni

The invention of aldosterone, how the past resurfaces in pediatric endocrinology

3 weeks 1 day ago
Sodium and water homeostasis are drastically modified at birth, in mammals, by the transition from aquatic life to terrestrial life. Accumulating evidence during the past ten years underscores the central role for the mineralocorticoid signaling pathway, in the fine regulation of this equilibrium, at this critical period of development. Interestingly, regarding evolution, while the mineralocorticoid receptor is expressed in fish, the appearance of its related ligand, aldosterone, coincides with...
Say Viengchareun

C-reactive protein and haemoglobin level in acute kidney injury among preterm newborns

3 weeks 2 days ago
Aim To explore the possibility of C-reactive protein (CRP) and haemoglobin (Hb) in prediction and risk assessment of acute kidney injury (AKI) among preterm newborns. This is believed to be closely related to the incidences of AKI, and could be the most affordable in early detection of AKI. Methods A case control study was carried out at Dr Hasan Sadikin Hospital in Bandung with a total of 112 preterms divided into two groups: with and without AKI based on the neonatal KDIGO (Kidney Disease:...
Fiva Aprilia Kadi

Characterization of perfusion decellularized whole animal body, isolated organs, and multi-organ systems for tissue engineering applications

3 weeks 3 days ago
To expand the application of perfusion decellularization beyond isolated single organs, we used the native vasculature of adult and neonatal rats to systemically decellularize the organs of a whole animal in situ. Acellular scaffolds were generated from kidney, liver, lower limb, heart-lung system, and a whole animal body, demonstrating that perfusion decellularization technology is applicable to any perfusable tissue, independent of age. Biochemical and histological analyses demonstrated that...
Doris A Taylor

Improved efficiencies in the generation of multigene-modified pigs by recloning and using sows as the recipient

3 weeks 4 days ago
This study was performed to improve production efficiency at the level of recipient pig and donor nuclei of transgenic cloned pigs used for xenotransplantation. To generate transgenic pigs, human endothelial protein C receptor (hEPCR) and human thrombomodulin (hTM) genes were introduced using the F2A expression vector into GalT-/-/hCD55+ porcine neonatal ear fibroblasts used as donor cells and cloned embryos were transferred to the sows and gilts. Cloned fetal kidney cells were also used as...
Jongki Cho

Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality

4 weeks ago
Intraventricular hemorrhage (IVH) and acute kidney injury (AKI) are important neonatal morbidities in premature infants. This study aimed to investigate the relationship between IVH and AKI in premature infants and whether this association affects the incidence of neonatal mortality. Infants [gestational age (GA) ≤ 32 weeks; birth weight (BW) < 1500 g] were retrospectively evaluated in a large tertiary neonatal intensive care unit. Of 710 premature infants, 268 (37.7%) developed AKI. Infants...
Mountasser M Al-Mouqdad

Epidemiology of Acute Kidney Injury After Neonatal Cardiac Surgery: A Report From the Multicenter Neonatal and Pediatric Heart and Renal Outcomes Network

4 weeks 1 day ago
CONCLUSIONS: Cardiac surgery-associated acute kidney injury occurs frequently after neonatal cardiac surgery in both cardiopulmonary bypass and noncardiopulmonary bypass patients. Rates vary significantly across hospitals. Only stage 3 cardiac surgery-associated acute kidney injury is associated with mortality. Cardiac surgery-associated acute kidney injury was not associated with any other outcomes. Kidney Disease Improving Global Outcomes criteria may not precisely define a clinically...
Jeffrey A Alten

X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3

1 month ago
The X-linked GRIA3 gene encodes the GLUA3 subunit of AMPA-type glutamate receptors. Pathogenic variants in this gene were previously reported in neurodevelopmental diseases, mostly in male patients but rarely in females. Here we report a de novo pathogenic missense variant in GRIA3 (c.1979G>C; p. R660T) identified in a 1-year-old female patient with severe epilepsy and global developmental delay. When exogenously expressed in human embryonic kidney (HEK) cells, GLUA3_R660T showed slower...
Jia-Hui Sun